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- Análisis de datos en OCDS en Chile
- Patricia Heredia Gil CEO de Minivinci
- (PDF) Farmacologia | per santiago - japan-solution.jp
Few studies have assessed the loss of efficacy or patient and caregiver satisfaction with rapid infliximab infusions. The aim of this study is to assess the tolerability, loss of efficacy and to describe the impact on resource utilization and patient satisfaction in rapid infliximab infusions. Subjects with inflammatory bowel disease receiving rapid infliximab infusions were included in the study.
Subjects received maintenance infusions from June to June Incidence of adverse reactions and the total number of rapid infliximab infusions were recorded.
Análisis de datos en OCDS en Chile
Efficacy was compared to published studies evaluating the long-term efficacy of infliximab infusions. Patient satisfaction was addressed through a survey following the implementation of the rapid infusion protocol.
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Seventy-five subjects with IBD were included in the study. Five hundred and twenty-two rapid infliximab infusions were provided to patients. There were no acute or delayed infusion reactions. Rapid infliximab infusions do not appear to increase the risk of loss of response compared to historical studies of long-term infliximab efficiency. A rapid infliximab infusion protocol improved efficiency in our infusion unit and increased patient and nursing satisfaction.
A patient with rheumatoid arthritis presented with bilateral PUK following a 2-month history of ocular discomfort and redness. His systemic prednisolone PDN and methotrexate MTX were increased and, despite an initial favorable response, bilateral recurrent corneal perforations ensued. Both eyes underwent cyanoacrylate glue repair, amniotic membrane transplantation AMT, and penetrating keratoplasty PKP. Recurrence of the disease and bilateral perforations of the second PKP in both eyes prompted administration of intravenous infliximab immediately after the fourth PKP.
The disease activity rapidly settled in both eyes, and at eighteen-month followup, after 12 infliximab infusions, the PUK remains quiescent with no further graft thinning or perforation. Infliximab can be used to arrest the progression of severe bilateral rheumatoid PUK in cases that are refractory to conventional treatment.
Presentación de un caso de aplicación de la dieta cetogénica en la epilepsia refractaria Presentation of a case of ketogenic diet application to refractory epilepsy. Se establece el régimen de alimentación cetogénico de instalación progresiva, sin período de ayuno inicial, y se observa un cambio clínico en el paciente a partir de que se logran niveles de cetosis, constatados por la aparición de cuerpos cetónicos en la orina.
Se concluye que no se debe renunciar a esta alternativa de tratamiento en los casos de epilepsia refractaria. The case of a 2-year-old male patient suffering from West syndrome that had been treated with multiple antiepileptic drugs without encouraging results, neither in the seizures, nor in his psychomotor development, which was seriously affected, was reported. A progressive ketogenic diet was established without initial fasting, and it was observed a clinical change in the patient, since ketosis levels were attained and confirmed by the appearance of ketone bodies in urine.
The clinical changes consisted in the reduction of the number of daily seizures and their intensity, in the possibility of stopping the use of one of the antiepileptic drugs, and in the increase of the level of sleeplessness of the patient. It was concluded that this treatment alternative should not be rejected in the cases of refractory epilepsy. Infliximab treatment in a patient with rheumatoid arthritis on hemodialysis. We describe a year-old woman with active rheumatoid arthritis RA and endstage renal disease secondary to hypertensive nephrosclerosis undergoing hemodialysis.
She had tried multiple antirheumatic medications; however, their usefulness was limited due to toxic side effects or lack of efficacy. She was then treated with chimeric antitumor necrosis factor monoclonal antibody infliximab , which resulted in immediate improvement in clinical and laboratory measures. After about 2 years of therapy, no side effects have been observed.
This report expands the spectrum of infliximab to include RA patients with renal insufficiency. It is important to determine the effects of immunomodulators on the ability of children to remain on infliximab therapy for Crohn's disease durability of therapy , given the potential benefits and risks of concomitant therapy-especially with thiopurines in male patients.
We investigated how immunomodulatory treatment affects the durability of infliximab therapy. We collected data from the Pediatric Inflammatory Bowel Disease Collaborative Research Group Registry, from January through August , on children with Crohn's disease who participated in a prospective multicenter study. Data were collected from patients who received at least a 3-dose induction regimen of infliximab , and their concomitant use of immunomodulators: no thiopurine or methotrexate treatment, treatment for 6 months or less during infliximab therapy, or treatment for more than 6 months during infliximab therapy.
Age, sex, and disease extent or location did not affect the durability of infliximab therapy. Greater length of concomitant use of immunomodulators was associated with increased time of infliximab therapy. The probability that patients with more than 6 months of immunomodulator use remained on infliximab therapy for 5 years was 0. In boys, methotrexate appears to increase the durability of.
Infliximab TNF-alpha antagonist decreases intraabdominal adhesions.
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Kurukahvecioglu, O. Objective was to evaluate the effect of infliximab on adhesion formation and its associated morbidity and complications. Thirty-five rats were randomly divided into 4 groups. After cecal abrasion 0. Adhesion formation was evaluated with macroscopic adhesion scoring systems. Peritoneal fluid samples and mesenteric lymph node biopsies were taken to rule out bacterial peritonitis.
Blood and peritoneal irrigation fluids samples were taken to measure the Tumor necrosis factor-alpha TNF-alpha levels. Macroscopic adhesion scores showed fewer adhesions in the infliximab group. The infliximab group had significantly fewer adhesions than the abrasion control and saline groups. According to the histological findings, there were no statistically significant differences between the groups. Early blocking of the activity of TNF-alpha after cecal abrasion resulted in lower rates of adhesion formation, macroscopically.
Patricia Heredia Gil CEO de Minivinci
The TNF-alpha, a proinflammatory cytokine appears to be an important mediator for postoperative adhesion formation. Infliximab Revellex R : a promise fulfilled? JP Wright. Full Text Available Intestinal anastomosis healing is a complex physiological process in which many local and systemic factors play a role.
(PDF) Farmacologia | per santiago - japan-solution.jp
In this study it was aimed to determine whether or not there was any negative effect of preoperative single dose infliximab treatment on intestinal anastomosis healing. Two groups of 10 rats were formed.
Four days after the infusion, a full layer incision was made to the colon and anastomosis was applied to all the rats. At 7 days after anastomosis, the subjects were sacrificed. The anastomosis segment was removed and the bursting pressure was measured. Tissue samples were taken from this segment for hydroxyproline concentration and histopathological examination.
No statistically significant difference was determined between the groups in terms of bursting pressure, tissue hydroxyproline concentration or histopathological scoring.
The US Food and Drug Administration is considering an application for a biosimilar version of infliximab , which has been available in South Korea since November The aim of the present study was to examine the utilization patterns of both branded and biosimilar infliximab and other tumor necrosis factor TNF inhibitors in South Korea before and after the introduction of this biosimilar infliximab. Using claims data from April to March from the Korean Health Insurance Review and Assessment Service database, which includes the entire South Korean population, the number of claims for biosimilar infliximab was assessed.
A segmented linear regression model was used to examine the utilization patterns of infliximab the branded and biosimilar versions and other TNF inhibitors adalimumab and etanercept before and after the introduction of the biosimilar infliximab. In total, 20, TNF inhibitor users were identified from the South Korean claims database, including with a prescription claim for biosimilar infliximab. During the first 15 months since its introduction in South Korea, one-fifth of all infliximab claims were for the biosimilar version. Introduction of biosimilar infliximab may affect the use of other TNF inhibitors, and the magnitude of change in usage will likely differ in.
It is used as chemotherapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary cancers. Several studies have reported that infliximab ameliorates cell damage by reducing cytokine levels. Aims: We aimed to investigate whether infliximab has a preventive effect against cisplatin-induced hepatotoxicity and whether it has a synergistic effect when combined with Cis.
Study Design: Animal experimentation. Each group comprised 10 animals.